Keyur P. Biology...Science Rasmussens Encephalitis The Human Immune Sy

Keyur P. Biology...Science Rasmussen's Encephalitis The human immune system is an amazing system that is constantly on the alert protecting us from sicknesses. Thousands of white blood cells travel in our circulatory system destroying all foreign substances that could cause harm to our body or to any of the millions of processes going on inside. Now imagine a condition where this awesome system turns against the most complex organ in the human body, the brain. Deadly as it is, this condition is known as Rasmussen's encephalitis. The meaningful research on Rasmussen's encephalitis was begun (unintentionally) by Scott Rogers and Lorise Gahring, two neurologists, who were at the time measuring the distribution of glutamate receptors in the brain. Later on when more provocative information was found they enlisted the help of James McNamara and Ian Andrews, epilepsy experts at Duke University Medical Center. The details on Rasmussen's encephalitis were very bleak at the time when the men began their research. All that was known is that Rasmussen's encephalitis was a degenerative disease of the brain that caused seizures, hemiparesis, and dementia normally in the first ten years of life. The seizures that were caused by Rasmussen's encephalitis were unstoppable by normal anti-seizure drugs used conventionally. What the worst part of the disease was that the pathogenesis for it were not known and even worse was how it developed. The first clue was delivered when Rogers and Gahring were trying to register the distribution of the glutamate receptors using antibodies, that tag on to the receptor itself. The proteins that make up the glutamate receptors(GluR) are only found inside the blood brain barrier(BBB). Glutamate and a few related amino acids are the dominant form of excitatory neurotransmitter in the central nervous system of mammals. If one of these GluRs happens to wander into the actual bloodstream, that is outside the BBB, it would be considered an outsider and destroyed immediately. So if these GluRs were put into the normal blood stream then the immune system would produce antibodies which could then be used in the searching for the glutamate receptors. In order to test this theory the researchers injected the GluRs into the blood stream of a normal healthy rabbit hoping to produce good results. At this point the experiment took a dramatic turn, after receiving a few doses of the protein two of the three rabbits began to twitch, as though they were suffering the pain of an epileptic seizure. Now the help of McNamara and Andrews was enlisted. When McNamara and Andrews examined the brain tissue of the rabbits, they saw what seemed to be a familiar inflammatory pattern, clumps of immune cells all around blood vessels. This description exactly matched the description of persons suffering from Rasmussen's encephalitis, moreover something as this would never be found in a healthy brain. A healthy br ain has its blood capillaries enclosed in the BBB membrane, so such a case as the one mentioned above would not be possible. As protective as the BBB is, it can be breached by something like a head injury. What was happening was that the antibodies which were out to get the GluR proteins were somehow finding a way into the brain and directing an attack towards all GluR receptor proteins in the brain itself. After some more examinations Rogers and McNamara decided that these attacks were the cause of the seizures that are often experienced by sufferers of Ramussen's encephalitis. Then if the case is of antibodies in the bloodstream, than sufferers of Ramussen's encephalitis should have them in their bloodstream and healthy normal peoples shouldn't. When this was actually tested the results were positive that Rasmussen sufferers did have these antibodies in their bloodstreams and healthy people did not. These were not only the right kind of antibodies but, the very antibodies that caused the seizures in people and rabbits. Thus when these antibodies were removed by plasma exchange(PEX) it caused a temporary relief from the seizures but soon the body starts making more antibodies of the type and the seizures start once again. After all the examinations two questions remained, why does the body mount an immune response against one of its own brain proteins,

Fasting; Muslim community Essays

Fasting; Muslim community Essays Fasting; Muslim community Essay Fasting; Muslim community Essay debut What and how fasting works towards Muslims, how it affect Muslim community, and deduction. Ethical The significance of Sawm or fasting is abstaining from morning to sunset from feeding, imbibing and sex. Like supplication, this act of worship has been portion of the shariah jurisprudence given by all the Prophetss. Their followings fasted as what Muslim nowadays does. However the regulations, the Numberss of yearss and the period prescribe for fasting has varied from one shariaah to another. Today, although fasting remains a portion of most faiths in some signifier or other, people have frequently changed its original signifier by accumulations of their ain. albaqarahpuasa O you who believe! fasting is prescribed for you, as it was prescribed for those before you, so that you may guard ( against immorality ) . Fasting is the forth constituent in the five pillars of Islam. It is a compulsory act that each and every Muslim must finish during the month of Ramadan. Normally, it last for a turn a month depending the anak bulan. Once the anak bulan has shown up, the governments will denote to the Muslim in that whole country sing the starting of Ramadan. Muslim who is able and da smpai akhil baligh MUST finish this spiritual pattern every twelvemonth or they will be in a serious problem in the afterlife. In the instance that person has to interrupt the fast, he/she must replace the same figure that he/she left after Ramadan ends. This symbolizes the equality of human being in the eyes of God. No 1 could get away from the obligatory acts†¦ . : There are several supererogatory ( optional ) fasting that can be done outside the month of Ramadan such as puasa sunat isnin khamis, puasa hari arafah, puasa asyura, puasa syaaban, puasa tengah bulan, and puasa enam dlam bulan syawal. Each one of it has a peculiar event in the yesteryear that Muslim should retrieve and larn from them. Social map Islam aims to transform the whole life of adult male into a life of worship. He is born slave and to function his Godhead is his very nature. Not for a individual minute should he populate without idolizing that is subjecting to Him in idea and workss. This can be seen in verse 56 sura AZ Zarriyat which says, I have non created genie and work forces except to idolize me . All other spiritual patterns involve some outward physical motion, but non the fasting. When praying, Muslim base, ruku ( bow down ) and sujud ( prostate ) which these motions are seeable to everyone. During hadj, 1000000s of Muslim disciples will garner at Mecca to finish the prescribe acts. Almsgiving excessively, is known to at least two individuals, the giver and the receiving system. None of this spiritual pattern can stay conceal as when Muslim execute them, we would come to cognize about it. But fasting is wholly different signifier of spiritual pattern which is kept wholly private. Merely Allah entirely knows whether or non a individual is fasting. Moslem disciples are required to take nutrient before morning and abstain from feeding and imbibing anything till the interruption the fast. But if any of them in secret eat and imbibe in between, cipher except the God will cognize about it. The private nature of the fasting ensures that Muslim has strong religion in Allah as the 1 who knows everything. Merely if their religion is strong and true, they will non woolgather of feeding or imbibing in secret even in the hottest summer or when experiencing really hungry. It is the feelings of taqwa ( fright ) that prevent them from making such things because they believe there will be a wages and penalty in the afterlife. The month of Ramadan is earmarked for all Muslims to fast together, to guarantee similar consequence. This step turns single Ibadah into corporate Ibadah . Just as the figure one when multiplied by 1000000s, becomes a formidable figure, so the moral and religious benefit accruing from the Fasting by one individual entirely are increased a million crease if a million people fast together. Besides, during Ramadan, it creates the ambiance of righteousness, virtuousness and piousness. As flowers bloom during spring, so does taqwa in Ramadan. Everyone would remain off from bad behaviours or wrongdoing that could ensue in acquiring more wickedness which wholly oppose the intent of fasting. Everyone will seek to maximise their yearss with good workss which create a really harmonious ambiance in the community. Muslim will make good plants, feed the hapless, dress the bare, help those in hurt, take part in any good work being done anyplace and forestall immorality. Just as workss have their season of blossoming, Ramadan is the clip of twelvemonth for the growing and flourishing of good and righteousness. Every good title of a adult male is granted multiplex addition, ten to seven hundred times. But says Allah: fasting is an exclusion ; it is entirely for Me and I reward for it every bit much as I wish. ( bukhari Muslim ) All good workss turn and this shows in proportion to both the purpose of the actor every bit good as their consequence, but there is a bound to their growing. The fasting nevertheless has no such bound. In Ramadan, in the season for the flourishing of good and piousness, non one 1000000s of people jointly H2O this garden of virtuousness. The more you unfeignedly perform goods workss in this month, the greater you avail yourselves of its approval, the more you will radiate their benefit to our brothers. deduction Some people might reason that fasting could do fatigue and establishes an unproductive people. However, fasting does convey more good than injury. First, the relationship between God and homo is acquiring nearer. This is really of import so that homo would act harmonizing to the instructions which are in general, making good things and avoiding any wickednesss.

Compare a character in Beloved with a character in one of the other Essay

Compare a character in Beloved with a character in one of the other texts we have read OR Compare a theme in Beloved with a theme in one of the other texts we h - Essay Example s the fictionality of history, the concept that history can never be more than a collection of stories with varying degrees of accuracy and numerous different perspectives. She demonstrates this fictionality of history through her main character Sethe as well as in the narrative structure, making it clear that no amount of storytelling will ever be able to contain the true horror of those days. During the time of Shakespeare, fiction was deemed to be the appropriate place for explorations into a nation’s history perhaps because of a similar understanding that there is no means of separating individual human perspective from historical events sufficiently to form an actual, factual history, thus recognizing the same concept of a fictionality of history. One author who certainly understood this concept was Miguel de Cervantes as shown in his Don Quixote. Through the various narrative styles employed as well as through the storyline, Cervantes is able to make his point that no hi storical account can be completely free of some fictionalized element. Thus, despite the wide gap of time between the writing of these two novels, both Morrison’s postmodern book Beloved (1988) and Cervantes’ Don Quixote written in the early 1600s struggle to illustrate both the concept of history as well as the inherent fiction that must accompany history. In Beloved, for example, Morrison establishes quickly that she is relating a story that took place in the past, even establishing the date to relate its proximity to the end of slavery: â€Å"For years each put up with the spite in his own way, but by 1873 Sethe and her daughter Denver were its only victims† (Morrison, 1988: 3). This establishes the novel’s fictional ghost story element, but only as it could occur in a society such as that which existed in 1873. The story of slavery is told in the bits and pieces that were left, â€Å"in all of Baby’s life, as well as Sethe’s own, men and women were moved around like

Transport Demand Management Essay Example | Topics and Well Written Essays - 1250 words

Transport Demand Management - Essay Example The question is what is TDM? There has never been one single key definition of TDM. Some have defined it as an overall term for the strategies that lead to a better proficient utilisation of transport resources. Others have defined it as an all-encompassing term given to strategies that enhance the transport system’s efficiency. It has also been defined as a wide range of measures that transfer or decrease roadway utilisation, hence, boosting the life and efficacy of the whole transport system (Zhou, 2008). Thus, it is evident that TDM is not a linear but an all-inclusive term that can be explained from different perspectives. Over the years, the measures used in TDM have involved alternates to drive-alone like transit. Such alternatives are attained through the availing of disincentives and incentives to alter travel features among commuters. At present, these measures now involve programs and policies to solve issues like the choice of location, time, route, and information using technology. TDM is been viewed with an ever growing importance due to the rise of traffic congestion in suburban areas as urban areas are faced with complications in the expansion of highways and environmental issues like air pollution get bigger (Weiner, 2012). TDM measures can be grouped into organisational and operational, financial, and infrastructure. Of these three groups, infrastructure can be regarded as the most visible of them all. Why is this so? It is so because it involves the building and changing of the structures that are used in transport. As a measure, there is a belief that using infrastructure as a measure in TDM produces expected results as it directs the usage of transport means much more easily even without the use of new policies. As a measure, it has received widespread support among all industry shareholders. In the UK for example, the Roads for Prosperity publication received nationwide support. The program aimed at taking

Virtue - Ontology Essay Example for Free

Virtue Ontology Essay Many people associate Plato with a few central doctrines that are advocated in his writings: The world that appears to our senses is in some way defective and filled with error, but there is a more real and perfect realm, populated by entities (called â€Å"forms† or â€Å"ideas†) that are eternal, changeless, and in some sense paradigmatic for the structure and character of the world presented to our senses. Among the most important of these abstract objects (as they are now called, because they are not located in space or time) are goodness, beauty, equality, bigness, likeness, unity, being, sameness, difference, change, and changelessness. (These terms—â€Å"goodness†, â€Å"beauty†, and so on—are often capitalized by those who write about Plato, in order to call attention to their exalted status; similarly for â€Å"Forms† and â€Å"Ideas. †) The most fundamental distinction in Platos philosophy is between the many observable objects that appear beautiful (good, just, unified, equal, big) and the one object that is what beauty (goodness, justice, unity) really is, from which those many beautiful (good, just, unified, equal, big) things receive their names and their corresponding characteristics. Nearly every major work of Plato is, in some way, devoted to or dependent on this distinction. Many of them explore the ethical and practical consequences of conceiving of reality in this bifurcated way. We are urged to transform our values by taking to heart the greater reality of the forms and the defectiveness of the corporeal world. We must recognize that the soul is a different sort of object from the body—so much so that it does not depend on the existence of the body for its functioning, and can in fact grasp the nature of the forms far more easily when it is not encumbered by its attachment to anything corporeal. In a few of Platos works, we are told that the soul always retains the ability to recollect what it once grasped of the forms, when it was disembodied prior to its possessors birth (see especially Meno), and that the lives we lead are to some extent a punishment or reward for choices we made in a previous existence (see especially the final pages of Republic). But in many of Platos writings, it is asserted or assumed that true philosophers—those who recognize how important it is to distinguish the one (the one thing that goodness is, or virtue is, or courage is) from the many (the many things that are called good or virtuous or courageous )—are in a position to become ethically superior to unenlightened human beings, because of the greater degree of insight they can acquire. To understand which things are good and why they are good (and if we are not interested in such questions, how can we become good? ), we must investigate the form of good.

THESECRT GARDEN :: essays research papers

The Secret Garden The book was about a girl, a wealthy one, who lived in India. Her name was Mary. Mary always thought her parents never paid attention to her and was too busy with parties. Mary was always angry, but she never cried. She thought her mom didn’t care about her until one day, when her parents died. After her parents died she went with this lady named Mrs. Madlock. She was going to her uncle’s that Mary had never met before, Mrs. Madlock said. On the carriage-ride to her uncles, is when she found out exactly where she was going. Mary also found out that her mother had a twin sister, which was her uncle’s wife. But, she had died also. She was said that she had died from falling off a swing in her garden. She had reached her uncle’s house, but she didn’t get to meet him, just yet. Her orders were to get some rest and maybe she could see him in the morning. The next morning she met Martha, Mrs. Madlock’s servant. After she was told to stay in her room she found a passage-door where it led to a dusty old room. She thought it most have been her Aunt’s room because it had matching things as her mother. In that room she found a big key, an odd-looking key.   Ã‚  Ã‚  Ã‚  Ã‚  That day she went outside to play. She wasn’t sure whom to play with; she didn't have any friends that didn't live in India. She found a robin, which led her to a door, a locked door. It had a keyhole that look as if the key in her aunt’s bedroom would fit. She got the key from the bedroom and it slides in perfect. She opened the big door and looked around, she saw how beautiful everything was and a wooden swing. Then she saw a boy. The boy’s name was Dickon; he was Martha’s brother. She and Dickon became friends and they planted many flowers together.   Ã‚  Ã‚  Ã‚  Ã‚  A couple of nights later when she was wandering around the house like she shouldn’t have she heard a boy. She went to go see who it was. It was her cousin, Colin. She has never met him either, she didn’t even know she had a cousin, nor an uncle. Colin has been in bed all his life, he was â€Å"sick†. Mary talked to him and became friends. THESECRT GARDEN :: essays research papers The Secret Garden The book was about a girl, a wealthy one, who lived in India. Her name was Mary. Mary always thought her parents never paid attention to her and was too busy with parties. Mary was always angry, but she never cried. She thought her mom didn’t care about her until one day, when her parents died. After her parents died she went with this lady named Mrs. Madlock. She was going to her uncle’s that Mary had never met before, Mrs. Madlock said. On the carriage-ride to her uncles, is when she found out exactly where she was going. Mary also found out that her mother had a twin sister, which was her uncle’s wife. But, she had died also. She was said that she had died from falling off a swing in her garden. She had reached her uncle’s house, but she didn’t get to meet him, just yet. Her orders were to get some rest and maybe she could see him in the morning. The next morning she met Martha, Mrs. Madlock’s servant. After she was told to stay in her room she found a passage-door where it led to a dusty old room. She thought it most have been her Aunt’s room because it had matching things as her mother. In that room she found a big key, an odd-looking key.   Ã‚  Ã‚  Ã‚  Ã‚  That day she went outside to play. She wasn’t sure whom to play with; she didn't have any friends that didn't live in India. She found a robin, which led her to a door, a locked door. It had a keyhole that look as if the key in her aunt’s bedroom would fit. She got the key from the bedroom and it slides in perfect. She opened the big door and looked around, she saw how beautiful everything was and a wooden swing. Then she saw a boy. The boy’s name was Dickon; he was Martha’s brother. She and Dickon became friends and they planted many flowers together.   Ã‚  Ã‚  Ã‚  Ã‚  A couple of nights later when she was wandering around the house like she shouldn’t have she heard a boy. She went to go see who it was. It was her cousin, Colin. She has never met him either, she didn’t even know she had a cousin, nor an uncle. Colin has been in bed all his life, he was â€Å"sick†. Mary talked to him and became friends.

Soil Liquefaction Dangers During Arthquake

Ground shaking and shifting can cause major damage, tearing apart houses, buildings, and roads. †¢Flooding that arises from broken water dams or river levees is another hazard. †¢Tsunamis, triggered by an undersea earthquake as well as seiches – waves coming from lakes shaken by a temblor – can submerge whole communities, sweep away edifices, topple trees and drown people. †¢Fire is another seismic hazard. It can flare up from broken gas and power lines, or from overturned wood, coal, or gas stoves. But there’s another major earthquake danger that not many are familiar with. Soil liquefaction is a phenomenon that occurs when soil mixes with groundwater during a moderate or strong earthquake, turning the ground into quicksand in minutes. Soil Liquefaction in Low-Elevation Areas Because the soil must be saturated for liquefaction to take place, it is more likely to occur in low-lying areas that are near bodies of water such as rivers, lakes, bays and oceans. It happens most often in areas with sandy soil, where water takes hours to wend its way through the tiny channels of the mixture. More resistant to liquefaction are large-grained, permeable soils like gravel, which drains quickly, and clay soil, where particles are packed closely together.. It was in 1964, when earthquakes shook Niigata, Japan, and Anchorage, Alaska, that soil liquefaction was recognized as a major cause of earthquake damage. Scientists have since linked it to major historical earthquakes worldwide. Soil liquefaction inflicts great damage to property. Since the ground is too unstable to withstand pressure, anything resting above the mush—a building, a bridge, a house, a pier, a runway, a nuclear power plant, an earth dam—may lean, tip over, split open, or sink several feet. Ways to Reduce Soil Liquefaction Risks What can be done if a soil has been identified as susceptible to liquefaction? An undergraduate research paper written by Alisha Kaplan lists three ways to reduce liquefaction risks when constructing new buildings and structures. †¢Avoid building on liquefaction-susceptible soils. Besides soil tests, vulnerable places can also be pinpointed by investigating past events in an area. Soils that had liquefied in previous seismic events can liquefy again if another quake occurs. †¢Erect liquefaction-proof structures. If construction on weak soil cannot be avoided, the structure’s foundation should be designed to resist the damaging effects of liquefaction. The building must be made ductile, equipped with adjustable supports, and constructed to withstand large deformations and span soft locations on the ground. †¢Improve the soil. Improvements should increase ground strength, density and draining capacity. Installing vibroflotation, vertical wick drains, compact piles, and stone columns can lower the possibility of liquefaction. Soil liquefaction cannot be taken lightly, especially by those living in suspected liquefaction-prone areas. With earthquakes seemingly in the news more often, it serves residents and authorities alike to take a look around them and assess if they are standing on firm ground, literally. Taking safety measures in advance can save lives and property should a calamity strike.